A Study on Correlation between Estrogen Receptor, Progesterone Receptor, Human Epidermal Growth Factor Receptor-2 Status and Other Prognostic Factors in Carcinoma Breast

INTRODUCTION: Breast cancer is now the most common cancer in woman .There are several factors which influence the development of breast malignancies such as the genetic background, reproductive parameters and the consequences of female hormones both intrinsic and extrinsic. Numerous studies have examined prognostic factors for survival of breast cancer patients, but relatively few have dealt specifically with relationship between hormonal receptor status, BMI and lymphovascular invasion. AIM AND OBJECTIVES: To study the correlation between hormonal receptors status (ER, PR, HER 2 NEU) and other prognostic factors like age, node, BMI, menopausal status, lymphovascular invasion in carcinoma breast. METHODOLOGY: All patients who fulfill the inclusion criteria were included in the study after obtaining written informed consents. Patient age, body mass index, tumour size, node, menopausal status is noted. The histopathology, ER, PR and HER-2/neu receptor status and lymphovascular invasion are obtained from trucut biopsy and specimen. The correlation of these prognostic factors was observed in our study. RESULTS: The mean age of carcinoma of breast was 48.5 years of age in our study. Positive receptor status (ER, PR & BOTH ER & PR) is strongly associated with normal BMI and decreased lymphovascular invasion. Negative receptor status (ER, PR & BOTH ER & PR) is strongly associated with obese patients and increased lymphovascular invasion in carcinoma breast. Normal BMI is associated with decreased lymphovascular invasion and obese BMI patients are associated with increased lymphovascular invasion in both pre and post-menopausal women. HER 2 NEU receptor status and node have no significant association with lympho vascular invasion and body mass index.