Addition of Neostigmine and Atropine to Conventional Management of Postdural Puncture Headache

BACKGROUND:Postdural puncture headache (PDPH) lacks a standard evidence-based treatment. A patient treated with neostigmine for severe PDPH prompted this study.METHODS:This randomized, controlled, double-blind study compared neostigmine and atropine (n = 41) versus a saline placebo (n = 44) for trea