Community Use of Epinephrine for the Treatment of Anaphylaxis: A Review and Meta-Analysis

ABSTRACT Background Community use of epinephrine for the treatment of anaphylaxis is low. Knowledge on rates of epinephrine use in the pre-hospital setting along with identification of barriers to its use will contribute to the development of policies and guidelines. Objectives A search was conducted on PubMed and Embase in April 2020. Our systematic review focused on four domains: 1) epinephrine use in the pre-hospital setting; 2) barriers to epinephrine use in the pre-hospital setting; 3) cost evaluation and cost-effectiveness of epinephrine use; and 4) programs and strategies to improve epinephrine use during anaphylaxis. Methods Two meta-analyses with logit transformation were conducted in order to: 1) calculate the pooled estimate of the rate of epinephrine use in the pre-hospital setting among cases of anaphylaxis and; 2) calculate the pooled estimate of the rate of biphasic reactions among all cases of anaphylaxis. Results Epinephrine use in the pre-hospital setting was significantly higher for children compared to adults [20.98% (95%CI: 16.38%, 26.46%) versus 7.17% (95%CI: 2.71%, 17.63%), respectively, p = 0.0027]. The pooled estimate of biphasic reactions among all anaphylaxis cases was 3.92% (95%CI: 2.88%, 5.32%). Our main findings indicate that pre-hospital use of epinephrine in anaphylaxis remains suboptimal. Major barriers to the use of epinephrine were identified as low prescription rates of epinephrine autoinjectors and lack of stock epinephrine in schools, which was determined to be cost-effective. Finally, in reviewing programs and strategies, numerous studies have engineered effective methods to promote adequate and timely use of epinephrine. Conclusion The main findings of our study demonstrated that across the globe, prompt epinephrine use in cases of anaphylaxis remains suboptimal. For practical recommendations, we would suggest considering stock epinephrine in schools and food courts to increase the use of epinephrine in the community. We recommend use of pamphlets in public areas (ie. malls, food courts, etc.) to assist in recognizing anaphylaxis and following that with prompt epinephrine administration, to avoid the rare risk of fatality in anaphylaxis cases.