Two Cases of Transient Focal Lesion in the Splenium of the Corpus Callosum after Aggravated Seizures

Transient focal lesions in the splenium of the corpus callosum have been rarely reported in epileptic patients receiving antiepileptic drugs. We examined two patients with epilepsy whose epileptic seizure frequency has drastically increased. The brain MRI findings of these patients showed a transient focal lesion in the splenium of the corpus callosum. Follow up MRI taken 15 days and 6 days later after controlling their seizures demonstrated complete resolution of the lesion, without specific treatment for the lesion.