Increased cholesterol absorption rather than synthesis is involved in boosted protease inhibitor-associated hypercholesterolaemia

Objective:The aim of this study was to compare the differential effects of first-line efavirenz (EFV)-based vs. boosted lopinavir-based antiretroviral regimens on cholesterol metabolism.Design:Multicentre, open-label, randomized clinical trial.Methods:Forty-nine naive HIV-infected patients were rand