Circulating tumor-associated antigen detected by the murine monoclonal antibody CF511 in human epithelial ovarian carcinoma

: The murine monoclonal antibody (Mab) to human common epithelial ovarian carcinoma, CF511, was generated by immunizing mice with human fetal tissue extract followed by a booster injection of ovarian cancer cells. Mab CF511 recognized the 600KD sialylated glycoprotein as being different from previously known tumor-associated marker antigens. Mab CF511 reacted with common epithelial ovarian carcinomas, and also reacted with breast and lung carcinoma. In normal tissue, Mab CF511 cross-reacted with the lungs, breast, thyroid, fallopian tubes and uterine endometrium. CF511 antigen was increased in sera of approximately 70% of the patients with common epithelial ovarian carcinoma. CF511 antigen levels in sera from patients with ovarian carcinoma corresponded to the clinical course. CF511 antigen was increased in only 3% of the 47 collections of sera from patients with benign gynecological diseases. These data suggests that CF511 antigen is a useful new ovarian tumor marker for the diagnosis and management of the disease.