Association of adenylate cyclase-2 gene polymorphism with bipolar disorder.

Abstract The pathogenesis of the Bipolar Disorder(BPD) is still unclear. Some studies suggest that abnormal signal transduction in specific pathways may play an important role in the pathogenesis of BPD ( Sui et al., 2015 ). Adenylate cyclase (ADCY) is an essential component of the adenylate signaling pathway. Previous studies have shown that some SNPs within the adenylate cyclase gene could affect the therapeutic response to mood stabilizers and antidepressants. Moreover, in 2014, one whole-genome study suggested that the ADCY-2 gene may be associated with BPD ( Muhleisen et al., 2014 ). This study aims to investigate the association between ADCY-2 gene polymorphism and BPD in Chinese Han population.