Diagnostic Values of the Prealbumin-to-Fibrinogen, Albumin-to-Fibrinogen, and Monocyte-to-Lymphocyte Ratios in Gastric Cancer.

OBJECTIVE This study aimed to assess the diagnostic value of the prealbumin-to-fibrinogen ratio (PFR), monocyte-to-lymphocyte ratio (MLR), and albumin-to-fibrinogen ratio (AFR) as single or combined indicators of gastric cancer. METHODS The study included 162 healthy controls and 155 patients with gastric adenocarcinoma. The differences in the experimental indicators and pathological characteristics between the groups were compared using the Kruskal-Wallis H test and Mann-Whitney U test. We evaluated the independent risk factors for gastric cancer through logistic regression and assessed the diagnostic values of PFR, AFR, and MLR for gastric cancer using receiver operating characteristic (ROC) curves. RESULTS PFR, AFR, and MLR were different between the healthy control and gastric cancer groups. PFR and AFR were related to the pathological characteristics of gastric cancer, such as tumor size, TNM stage, and clinical stage (P 0.05). Regression analysis suggested that PFR, MLR, and AFR might be independent factors predictive of gastric cancer. When combining PFR, MLR, and AFR, the area under the curve (AUC) was 0.951, and the sensitivity and specificity were 87.10% and 95.06%, respectively. This combination had the highest diagnostic value for gastric cancer patients. CONCLUSION The combination of PFR, MLR, and AFR is more valuable than each indicator alone in the diagnosis of gastric cancer.