Vitamin D for inflammation biomarkers in coronary artery disease: a protocol for systematic review and meta-analysis

BACKGROUND Coronary artery disease (CAD) is a clinically common coronary heart disease. Vitamin D might be beneficial in CAD patients through its favorable effects on inflammation biomarkers. This study will be performed to examine the effects of Vitamin D supplementation on inflammatory markers in CAD patients. METHODS We will search the electronical databases and hand-searching journals or reference lists. The study screening and data extraction will be carried out by 2 investigators independently. The primary outcome is inflammatory biomarkers of peripheral blood. Secondary outcomes are triglyceride, total cholesterol, high-density lipoprotein cholesterol levels, low-density lipoprotein cholesterol, and blood pressure. Review Manager (RevMan, version 5.3; The Nordic Cochrane Centre, Copenhagen, Denmark: http://community.cochrane.org) V.5.3 software will be used to compute the data. RESULTS The results of the study will provide a reliable evidence to assess the efficacy of Vitamin D supplement on inflammation biomarkers of CAD patients. CONCLUSION The conclusion of our systematic review will answer whether Vitamin D is an effective intervention to relieve inflammation of CAD patients. ETHICS Because all of the data used in this review has been published, this review does not require ethical approval. REGISTRATION NUMBER INPLASY202060072.