Novel dual purpose antimicrobials and co-formulates to regenerate currently redundant antimicrobials

The increased prevalence of antimicrobial resistant bacteria is the most significant challenge facing the human-health today in both developed and developing worlds. It's estimated that by the year 2050 antimicrobial resistant bacterial infections will be responsible for more deaths each year than cancer. The identification of novel antimicrobials is therefore a major priority. The proposers are currently investigating Supramolecular Self-associating Amphiphiles (SSAs) as a novel class of antimicrobial and co-formulate which have the potential to achieve these global objectives (Patent Application No. PCT/EP2018/069568). Within the scope of this proposal we wish to investigate the interaction of one such candidate SSA with a number of model membrane to elucidate the interaction mechanism providing invaluable information as to their mode of action to help optimise future synthetic design.