Tetrahydrohyperforin (IDN5706) targets the endoplasmic reticulum for autophagy activation: potential mechanism for Alzheimer's disease therapy.

Alzheimer's disease (AD) is the most common form of dementia worldwide among the older population. To date, there is no therapy to stop the destruction of brain cells and all the available treatments only compensate for the loss of synaptic transmission, thus resulting in marginal benefits to patients.