Graphene Oxide Based Fluorescent DNA Aptasensor for Liver Cancer Diagnosis and Therapy
2021
Graphene-oxide based
fluorescent DNA aptasensors for the in vivo application remain a challenging task. We demonstrate for the first time such a nanomaterial for in vivo diagnosis and
therapy of liver tumor with good biocompatibility and high selectivity. This DNA nanomaterial
comprising of
DNA tetrahedron and aptamers, aggregation-induced emission luminogen (AIEgens)
and antitumor drug doxorubicin,
is fabricated and attached on
GO surface. Additionally, this GO-based fluorescent DNA nanodevice is
also constructed by using microfluidic chip for liver
tumor cell screening.
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