In Situ Construction of Zeolitic Imidazolate Framework-67 Derived Co3O4 on CCCH NWs/CF Hierarchical Nanowires for High-Performance Enzymeless Glucose Detection

Abstract An ultrasensitive electrochemical glucose sensor was developed by hydrothermal growth of cobalt copper carbonate hydroxide nanowires (CCCH NWs) on copper foam (CF) and surface in situ growth of zeolitic imidazolate framework-67 (ZIF-67) derived cobalt oxide (Co3O4) (Co3O4@CCCH NWs/CF). Benefitting from the large accessible surface area, the heterojunction between Co3O4 and CCCH NWs, as well as the high electrical conductivity of copper foam, the electrochemical properties of Co3O4@CCCH NWs/CF sensor were significantly improved. As demonstration, we achieved an ultra-high sensitivity of 16.01 μA/μM/cm2, a wide linear range of 0.001∼2.0 mM, and remarkable fast response-recovery times (1.5 s and 1.3 s) for emzymeless glucose detection based on the optimized sensor. Moreover, the fabricated Co3O4@CCCH NWs/CF sensor has a good reproducibility, a long-term stability and anti-bending property for glucose detection. More interestingly, this sensor can be used to determine the glucose level of real serum samples, thereby providing a useful tool for enzymeless glucose monitoring.