Clinicopathological associations in temporal lobe epilepsy patients utilising the current ILAE focal cortical dysplasia classification

Summary Objectives This study utilised the revised 2011 ILAE classification of focal cortical dysplasia (FCD) ( Blumcke et al., 2011 ) to examine pathology in a cohort of children and adults who underwent temporal lobe epilepsy (TLE) surgery, and to describe the electroclinical and imaging features associated with these pathologies. Methods The sample population were children ( n  = 26) and adults ( n  = 47) who underwent TLE surgery between 2002 and 2011 at our institutions. Neuropathology and MRI studies were re-reviewed by experts blinded to the original diagnosis. EEG and clinical data including current seizure outcome were determined by patient file review and/or patient contact. Pre-operative data, post-operative outcome and pathological diagnoses were compared. Results The commonest pathology in the adult cohort was isolated hippocampal sclerosis (HS) ( n  = 24, 51.1%) and in the paediatric cohort, isolated tumour ( n  = 10, 38.5%). Overall, HS with associated FCD (FCD IIIA) was the third most common pathology ( n  = 12, 16.4%). Temporal grey matter signal changes on MRI were associated with FCD IIIA ( p  = 0.035). FCD IIIA had the poorest post-surgical seizure outcome compared to all other pathologies ( p  = 0.026). A history of bilateral convulsive seizures was more common in adults ( n  = 40, p p  = 0.045). Postoperatively, paediatric TLE had higher rates of seizure freedom ( p  = 0.005) and more children had ceased medication ( p Significance FCD IIIA is a comparatively common pathological subtype in TLE, with a poor post-surgical outcome. Pre-operative recognition of FCD IIIA may be feasible through grey matter signal change on MRI. Paediatric patients had a higher rate of seizure freedom than adults. Pre-operative bilateral convulsive seizures were associated with poor outcome after surgery.