Human papillomavirus type 18/16 infection and prevalence among middle-aged and older Chinese rural women: a cross-sectional survey in Wufeng, Hubei Province

ABSTRACTThis study aimed to measure the prevalence and potential factors related to HPV 16/18 infection among middle-aged and older Chinese rural women. The study was conducted among women aged 35–65 years in rural villages within Wufeng in Hubei Province. Data were collected using a pretested questionnaire between July and August 2015. Cervical specimens were collected for HPV DNA detection and typing by using careHPV. Pearson’s Chi-square and logistic regression analyses were used to examine associations with HPV positivity. Among 1001 participants, the prevalence of HPV 18/16 positive genotyping was 15.88% (n = 159). Husbands’ extramarital sex (adjusted odds ratio [OR] = 15.85, 95% confidence interval [CI] 5.76–43.59), cervicitis (adjusted OR = 9.27, 95% CI 5.06–16.99), condom usage (adjusted OR = 0.16, 95% CI 0.05–0.53), higher average number of live births (adjusted OR = 1.98, 95% CI 1.32–2.96 for two live births; adjusted OR = 3.29, 95% CI 1.39–7.81 for three or more live births) were associated wit...