Granulomatous Appendicitis Revisited: Report of a Case

Background: Isolated granulomatous appendicitis is uncommon and previously was considered to be a form of localised Crohn’s disease. However more recent series have noted that relapse is rare after appendicectomy and concluded that the condition is a distinct entity unrelated to Crohn’s disease. Following a case of granulomatous appendicitis at St. Vincent’s University Hospital Dublin, the condition was reviewed and the results are detailed herein. Methods: A case of granulomatous appendicitis is presented with discussion of 4 previous cases encountered in our practice and the literature is reviewed. Results: The clinical presentation was sub-acute appendicitis with a mass palpable in the right iliac fossa. At operation an enlarged, inflamed appendix with a broad base was noted and appendicectomy performed. Histopathology showed numerous granulomata on microscopic examination. The yersinia serology tests were negative. Review of computerised histopathology records in the hospital for the last 7 years showed 4 additional cases of granulomatous appendicitis. This is a total of 5 of 1,615 appendicectomies (an incidence of 0.31%). In all cases, the post-operative course was uneventful and the patients have had no further complaints. Conclusion: This small series provides further evidence that granulomatous appendicitis is a distinct clinical entity unrelated to Crohn’s disease and is cured by appendicectomy. It should be suspected when there is a sub-acute onset of appendicitis and an enlarged, broad-based appendix is found at operation.