The synthetic method of hydroxychloroquine

The present invention provides a kind of synthetic methods of hydroxychloroquine; the synthetic method is comprising steps of by 4; 7- dichloroquinoline, 5- (N- ethyl-N-2- hydroxyethylamino) -2- amylamine and N; the mixing of N- diisopropylethylamine; it is reacted under protective gas, after reaction by extracting, being concentrated, being refining to obtain hydroxychloroquine.Using synthetic method provided by the invention, n,N-diisopropylethylamine does attached sour agent and makees solvent again, promotes reaction to go on smoothly, while dosage is few (only theoretical amount), consumes low；Reaction time is short, and post-processes without alkalization, only can be prepared by hydroxychloroquine by the operations such as extraction and recrystallization, easy to operate；Same solvent can be used in extractant and recrystallization solvent, is conducive to the recycling of solvent, reduces production cost；Total recovery is increased to 74.7% from 45.9%, and product quality is increased to 99.8% (HPLC purity) or more by 99.0%, it is single it is miscellaneous≤0.1%.