Clinical Analysis of Primary Pulmonary Mucin-associated Lymphoid Tissue Lymphoma

Objective To investigate the clinical diagnosis and treatment of primary pulmonary mucin-associated lymphoid tissue lymphoma(MALToma) and to improve the knowledge of MALToma and to provide reference for treatment.Methods Seven cases of primary pulmonary MALToma were analyzed by clinical feature,radiographic and pathological characters,and meanwhile the related literatures were reviewed.Results The most common manifestations were recurrent cough and sputum.Chest computed tomography(CT) demonstrated high density shade of large soft tissues in pulmonary lesions with air bronchogram.Histopathology and immunohistochemical findings revealed that most of the tumor cells were widely positively stained for CD20 and CD79α,but negative for CD43,CD3,Syn,CgA and CD56.Conclusion Primary pulmonary MALToma is very rare with low grade B-cell types.It can be diagnosed with combination of the clinical characters,radiographic features,histopathology and immunophenotypic findings.