The clinical study of TRPV5 in renal tissues of patients with calcium-contained kidney stones

Objectives To study the clinical effcet of TRPV5 in the formation of calcium-contained kidney stones.Methods 56 patients with kidney stones treated by mPCNL between January 2012 and October 2012were enrolled.30 cases were calcium-contained kidney stones while 26 cases were non-calcium-contained kidney stones.Another 20 cases treated by nephrectomy of other reasons were enrolled as control group.The data of 24hour urine calcium and expression of TRPV5 in the kidney were studied in all the cases.Results The data of 24 hour urine calcium of calcium-contained kidney stones group were 8.59 ± 2.48 mmol,which were significant higher than that in other two groups(P ＜ 0.05).And the expression of TRPV5 in the kidney were also significant differences between calcium-contained kidney stones group and other two groups.Conclusions The reduced expression of TRPV5 in the kidney could contribute to the formation of calcium-contained kidney stones. Key words: Kidney Calculi