Microsatellite instability status in metastatic colorectal cancer and effect of immune checkpoint inhibitors on survival in MSI-high metastatic colorectal cancer.

Wataru Okamoto,Yoshiaki Nakamura,Manabu Shiozawa,Yoshito Komatsu,Tadamichi Denda,Hiroki Hara,Yoshinori Kagawa,Yukiya Narita,Hisato Kawakami,Taito Esaki,Tomohiro Nishina,Naoki Izawa,Koji Ando,Toshikazu Moriwaki,Takeshi Kato,Fumio Nagashima,Taroh Satoh,Shogo Nomura,Takayuki Yoshino,Kiwamu Akagi

Microsatellite instability status in metastatic colorectal cancer and effect of immune checkpoint inhibitors on survival in MSI-high metastatic colorectal cancer.

2019

e15106Background: Tumor mismatch repair (MMR) predicts benefit of immune checkpoint inhibitors (ICIs) in metastatic colorectal cancer (mCRC). We conducted a large-scale prospective observational tr...

Keywords:

Colorectal cancer
Cancer research
Immune checkpoint
Pathology
Microsatellite instability
Medicine
DNA mismatch repair
Oncology
Internal medicine
immune checkpoint inhibitors

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