Significance and Expression of PDGF-A,PDGF-B in Hilar Cholangiocarcinoma

Objective To study the relationship between platelet-derived growth factor(PDGF) and hilar cholangiocarcinoma(HCCA).Methods The expression of PDGF-A,PDGF-B was measured by immunohistochemistry in paraffin section of 42 patiens with HCCA.Results The expression of PDGF-A and PDGF-B was 62% and 52% of samples.The level of PDGF-A and PDGF-B were significantly different between control group(P0.01).Conclusion PDGF might paly an important role in HCCA,and the fur thur study might give a new way for diagnosis and treatment of HCCA.