Tu1380 Multicenter Preliminary Experience With the SEDASYS Propofol Infusion Pump for Colonoscopy in Routine Clinical Practice: Safety and Endoscopist Satisfaction

Tu1380 Multicenter Preliminary Experience With the SEDASYS Propofol Infusion Pump for Colonoscopy in Routine Clinical Practice: Safety and Endoscopist Satisfaction Anand Sahai*, John C. Wong, Michael Gould, Michael F. Byrne CHUM-Hopital Saint Luc, Montreal, QC, Canada; Vancouver General Hospital/University of British Columbia, Vancouver, BC, Canada; Vaughan Endoscopy Clinic, Vaughan, ON, Canada Background: When the endoscopy team includes only 1 nurse and 1 physician, the Sedasys propofol infusion pump, which is operated by the nurse, uses patient BMI to calculate the estimated infusion rate required to maintain light to moderate sedation for colonoscopy in ASA 1-2 patients that have been premedicated with a single 100 g dose of fentanyl. It then continuously monitors O2 saturation, capnography, respiratory rate, and patient responsiveness and lowers or stops the infusion as needed. If the physician wishes to increase the rate or give a PRN dose, the system will only allow so if the system’s algorithm deems the patient’s sedation level is not too deep. Aim: To report our early experience with Sedasys in routine clinical practice. Methods: Consecutive available case records and any available Sedasys case summary printouts from 3 centres (2 hospitals, 1 ASC) currently using Sedasys were reviewed for all available pertinent information. Results: As per product instructions, Sedasys was used only for colonoscopy patients, 70 yrs old, ASA 1-2, BMI 30, and with no history of sleep apnea. Since 2011, Sedasys was used in over 500 patients in 3 Canadian centers. Data for study purposes were available for 311 patients: 50% female, mean age 54 11, mean BMI 26 4. Primary indications were: screening 50%, bleeding 21%, other symptoms 17%, IBD 12%. All colonosocopies were completed to the cecum. Mean procedure length was 18 7 min. Mean propofol dose: 87 41mg [median 79mg]. O2 SAT%: mean -3.1 3.9, mean minimum: 95 4.1. Desaturation episodes: 92%: 17%, 85%: 2%. BPmmHg: mean : -24 18, mean minimum: 107 16. Hypotension: 90mmHg: 14%, 80mmHg: 3%. Endoscopist satisfaction: Of 14 users surveyed anonymously: 86% liked Sedasys, 86% found it more effective than endoscopistadministered non-propofol sedation, 100% found it convenient to use, and 93% would recommend it at least slightly strongly. Conclusions: Early clinical experience suggests that Sedasys is as safe as regular sedation, but is preferred by endoscopists to conventional, endoscopist-administered non-propofol sedation.