SYMPTOMATIC MANAGEMENT OF FUNCTIONAL DYSPEPSIA: EVALUATION OF EFFICACY AND SAFETY OF PUDIN HARA PEARLS AND PUDIN HARA LIQUID

Treatment of functional dyspepsia has been a preferential niche for natural remedies. Pudin Hara Pearls and Pudin Hara Liquid comprise extracts of Mentha sp. which are used traditionally to provide relief in symptoms of dyspepsia. Objective of the current study was to assess the efficacy and safety of Pudin Hara Pearls and Pudin Hara Liquid in symptomatic management of functional dyspepsia. 79 patients with functional dyspepsia were administe red either Pudin Hara Pearls (1 cap/tid) or Pudin Hara Liquid (10 drops/ tid) after meals for 5 days or resolution of symptoms, whichever was earlier. Eff icacy was assessed from baseline on basis of improvement in symptoms such as acid regurgitation, heart burn, stomach pain, up per abdominal bloating, nausea and the Investigator’s and the patient’s global evaluation of therapeutic response. Safety was ass es sed on basis of development of adverse events and changes in hematological and biochemical profiles . Pudin Hara Pearls and Pudin Hara Liquid produced significant improvement in symptoms of functional dyspepsia. Though there were no statistically significan t differences in comparative efficacy of study products, Pudin Hara Pearls were better on symptoms like acid regurgitation, upper abdominal bloating and nausea; and Pudin H ara Liquid was better in relieving feeling of acidity, loss of appetite and vomiting . No adverse events were reported with any of the study products. Results concluded Pudin Hara Pearls and Pudin Hara Liquid are effective in the management of symptoms functional dyspepsia and can be used safely .