Ventilatory constraint is more severe in walking than cycling in patients with COPD

Abstract Due to its effectivity in assessing functional capacity and adding prognostic information to the staging of chronic obstructive pulmonary disease (COPD) patients, the 6-minute walk test (6MWT) is extensively used in clinical evaluation. Currently, there is little information about the physiological response this test elicits in patients, especially when compared to cardiopulmonary exercise test (CPET). The aim of the study was to compare ventilatory and metabolic responses between these tests commonly used for the assessment of clinical outcome. A group of 20 patients with moderate to very severe COPD were tested for their pulmonary function (flow-volume curve, static lung volumes), occlusion mouth pressures and breath-by-breath measurement of flow, volumes, and oxygen (O2) and carbon dioxide (CO2) concentration during the 6MWT and CPET. All parameters measured during both exercise tests were assessed over the throughout of the tests and compared between each other at specified time points. Serially measured inspiratory vital capacity (IVC) decreased more rapidly and extensively during the walk-test (p