Clinical features of buried optic disc drusen with hemorrhage

Objective To investigate the clinical features of buried optic disc drusen with hemorrhage.Methods Retrospectively analyzed the data of 38 cases of buried optic disc drusen with epi-papillary hemorrhage,sub-retinal hemorrhage and/or pre-retinal hemorrhage (vitreous hemorrhage),all of which were diagnosed with fundus photography,fundus fluorescence angiography(FFA)and spectral-domain optical coherence tomography(SD-OCT),and thereafter the clinical characteristics of these cases were summarized.Results All patients had clinical symptoms,such as loss of visual acuity and shadows in front of the eyes.Of the 38 cases,38 subjects were noticed with epi-papillary hemorrhage and sub-retinal hemorrhage,and 8 with pre-retinal hemorrhage.Classic granular hyperfluorescence were seen in 23 cases at the late stage of FFA.On SD-OCT,buried optic disc drusen manifested itself as hyper-reflective nodular signal in the optic disc,pre-retinal hemorrhage and epi-papillary hemorrhage as hyper-reflective signals in front of retina and at the surface of papilla,and sub-retinal hemorrhage as hemorrhagic or serous neuroepithelial detachment.Conclusions All the buried optic disc drusens with hemorrhage were symptomatic,and the bleedings can locate at many layers,such as pre-retina,epi-papilla and sub-retina,which can be precisely diagnosed by SD-OCT in combination with fundus photography and FFA. Key words: Optic disc drusen;  Fundus fluorescence angiography;  Optical coherence tomograpgy/ spectral domain;  Medical imageological examination