Histopathological Profile of Urinary Bladder Tumours at Tertiary Care Centre in a Northern State of India: A Cross Sectional Study

Background: Urothelial carcinoma of urinary bladder cancer is the fourth most common cancer in men and eighth most common malignancy in women in the Western world. It is three times more common in men than in women and 90% of the bladder tumours are transitional cell carcinoma (TCC).Cystoscopic examination has a limited role in staging process for which transurethral resection (TURBT) of visible tumour down to the base is required which can accurately assess depth of tumour invasion. Design: This record based cross sectional study was carried out in the department of Pathology, Indira Gandhi Medical College, Shimla over a period of one year from January to December 2018. Data was collected from records using a structured clinical Performa which included various sociodemographic and clinical variables. WHO (2016)/ISUP classification was used to classify bladder tumours. Result And Disscussion: The mean age of presentation was 60 years with male female ratio 3.8:1. Majority (94.5%) of the malignancies were papillary urothelial carcinoma with equal proportion of high and low grade. Muscle invasion was significantly higher in high grade (78%) as compared to low grade papillary urothelial carcinoma (1.6%). These parameters were comparable to other studies. Conclusion: Among Urothelial tumours the most common bladder tumours, primary epithelial malignancies are more common. High grade urothelial carcinomas are usually associated with muscle invasion supporting correlation of histologic grade with aggressiveness. These findings were also seen in various other studies in literature.