Preclinical characterization of GNS561 as a novel first in class autophagy inhibitor to kill hepatocellular carcinoma cancer stem cells.

Firas Bassissi,Sonia Brun,Elena Patricia Gifu,Jérôme Courcambeck,Grégory Nicolas,Clarisse Dubray,Antoine Beret,Nolwenn Amrani,Claude Caron de Fromentel,Philippe Merle,Philippe Halfon

Preclinical characterization of GNS561 as a novel first in class autophagy inhibitor to kill hepatocellular carcinoma cancer stem cells.

2016

Firas Bassissi
Sonia Brun
Elena Patricia Gifu
Jérôme Courcambeck
Grégory Nicolas
Clarisse Dubray
Antoine Beret
Nolwenn Amrani
Claude Caron de Fromentel
Philippe Merle
Philippe Halfon

e15600Background: In spite of successful approval and wide application of sorafenib, the prognosis for patients with advanced hepatocellular carcinoma (HCC) remains poor. In recent years, highly tu...

Keywords:

Autophagy
Pathology
Hepatocellular carcinoma
Immunology
Cancer stem cell
Medicine
Sorafenib
Internal medicine
Oncology

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