Correlation of serum levels of bilirubin and uric acid with coronary heart disease

Objective To study the correlation of serum levels of bilirubin and uric acid with coronary heart disease. Methods According to the results of coronary angiography, 225 patients with coronary heart disease were enrolled as CHD group, and another 206 non-CHD subjects as control group. Serum levels of total bilirubin, direct bilirubin, indirect bilirubin, uric acid and blood lipids were measured, compared and analyzed among all groups. Results Compared with control group, serum levels of total bilirubin, direct and indirect bilirubin were significantly decreased [ (11.16±2.12) μmol/L vs. (16.45±2.36) μmol/L, (2.53±1.21) μmol/L vs. (3.35±2.11) μmol/L and (7.63±2.48) μmol/L vs. (9.52±3.27) μmol/L, respectively, all P<0.01], and serum uric acid, total cholesterol, triglyceride and low density lipoprotein-cholesterol significantly increased [ (369.82±95.62) μmol/L vs. (302.69±72.53) μmol/L, (5.13±1.48) mmol/L vs. (4.35±1.32) mmol/L, (1.65±0.23) mmol/L vs. (1.12±0.17) mmol/L and (3.26±1.24) mmol/L vs. (2.59±1.06) mmol/L, respectively, all P<0.01] in CHD group. Conclusions Decrease of serum bilirubin level and increase of serum uric acid level are related to occurrence of coronary heart disease. Key words: Coronary artery disease; Bilirubin; Uric acid