Ordered Accumulation of Mutations Conferring Resistance to Sulfadoxine-Pyrimethamine in the Plasmodium falciparum Parasite

Toshihiro Mita, Jun Ohashi, Meera Venkatesan, Aung Swi Prue Marma, Masatoshi Nakamura, Christopher V. Plowe, and Kazuyuki Tanabe Department of Molecular and Cellular Parasitology, Juntendo University School of Medicine, Tokyo, Japan, Department of International Affairs and Tropical Medicine, Tokyo Women’s Medical University, Japan; Doctoral Program in Life System Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaragi, Japan; Howard Hughes Medical Institute / Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, USA; Worldwide Antimalarial Resistance Network (WWARN) Molecular Module, Baltimore, MD, USA; Communicable Disease Control Division, Directorate General of Health Services, Ministry of Health & Family Welfare, Bangladesh Secretariat, Dhaka, Bangladesh; Department of Tropical Medicine and Parasitology, Dokkyo Medical University, Tochigi, Japan; and Department of Molecular Protozoology, Research Institute for Microbial Diseases, Osaka University, Japan