Differential Expression and Processing of Matrix Metalloproteinase 19 Marks Progression of Gastrointestinal Diseases (matrixmetalloproteinase19/inflammatoryboweldisease/macrophages/coloncancer/endothelium/ lymphaticvessels)

Matrix metalloproteinases (MMPs), re- sponsible for extracellular matrix remodelling and processing of numerous soluble and cell-surface pro- teins, appear to play important roles in pathogenesis of gastrointestinal diseases. MMPs influence migra- tion of inflammatory cells, mucosal destruction, ma- trix deposition and degradation. In this study, we analysed the expression of MMP-19 in the main forms of gastrointestinal diseases including inflam- matory bowel diseases (IBD) such as ulcerative coli-