Temperature‐Sensitive Artificial Channels through Pillar[5]arene‐based Host–Guest Interactions

In living systems, temperature-sensitive ion channels play a vital role in numerous cellular processes and can be controlled by biological ion channels in response to specific temperature stimuli. Facile pillar[5]arene-based host–guest interactions are introduced into a nanochannel pattern for constructing a temperature-sensitive artificial channel. Ion transport was switched from cations to anions by controlling the extent of the host bound to the guest with temperature stimuli. This efect is mainly due to the changing of the inner surface charge and wettability of the nanochannel during the process. This study paves a new way for better understanding the mechanism of temperature-sensitive properties and shows great promise for biomedical research.