Macrocomplexes and discordant high-sensitivity cardiac troponin concentrations:

BackgroundAnalytical comparisons between different high-sensitivity cardiac troponin (hs-cTn) assays are important for reassurance of results performed with different methodologies and to identify potential interferences or confounders to result interpretation. Our objective in the present study was to compare Beckman Coulter’s latest hs-cTnI assay to Abbott’s hs-cTnI assay and to assess agreement between results.MethodsTwo hundred ethylenediaminetetraacetic acid plasma samples that had clinically reported hs-cTnI results from the Abbott ARCHITECTi2000 that spanned the analytical range were stored (median = 4 h), re-centrifuged and retested for hs-cTnI on the Abbott ARCHITECTi1000 and Beckman Coulter Access2 analysers. Passing–Bablok regression and fold-differences were evaluated, with differences approximately three-fold between results further subjected to Roche hs-cTnT testing and polyethylene glycol precipitation.ResultsThe Beckman and Abbott hs-cTnI concentrations were correlated (r = 0.95) with Beck...