Incidence and possible predictors of sodium disturbance after craniopharyngioma resection based on QST classification.

Abstract Objective Serum sodium abnormalities are one of the most common manifestations following radical CP excision. The aim of this study was to report the incidence and possible predictors of serum sodium disturbance and explore features of sodium destabilization manifestation among QST classification results following craniopharyngioma resection. Methods A retrospective analysis of clinical, biochemical, radiological and operative data for 134 successive patients who underwent primary craniopharyngioma removal between September 2016 and March 2018 was performed. Univariate and multivariate analyses were conducted to determine predictors. Results Sixty (44.8%) patients experienced hyponatremia and 67 (50%) patients hypernatremia; the median time of onset was 6 days and the first day after surgery, respectively. The incidence, onset, severity and type of sodium disturbance among different types of craniopharyngioma differed significantly based on statistical tests(p＜0.05). Sodium disturbance was more common and severe in patients with type T tumors(p＜0.05). Age, tumor type and preoperative diabetes insipidus (DI) were independent prognostic factors for obvious disorders of serum sodium. Conclusions Hypo/hypernatremia is quite common following primary craniopharyngioma resection. The site of tumor origin has a direct effect on the growth pattern of CP, which may serve as a useful index for anticipating sodium perturbation following surgery. The level of sodium in children and patients with type T tumors, preoperative DI should be monitored closely throughout hospitalization.