Daily Changes of Nutritional Status in Partially Hepatectomized Rats Receiving Total Parenteral Nutrition

Daily changes of nutritional status during total parenteral nutrition (TPN) were studied in partially hepatectomized (PH) rats. When PH rats were parenterally infused with 8 to 10 g of amino acids and 40 to 60 g of glucose per kg daily for 1 to 3 days, the nitrogen balances in PH rats were positive during the infusion period, but the balance was significantly lower on day 3 than that in nonhepatectomized (NPH) rats. Urinary total catecholamine levels in PH rats tended to be higher (45 to 70%) than those in NPH rats. Throughout the infusion period, plasma Met and Phe levels were elevated, and plasma albumin and total protein levels were decreased in PH rats as compared with NPH rats. Marked increases of plasma GOT and GPT activities were observed in PH rats on day 1 and the elevated activities were gradually normalized during TPN. These results indicate that the nutritional status of PH rats was inferior to that of NPH rats under the TPN conditions but that TPN was rapidly restoring the nutritional status ...