Analysis on risk factors of hearing impairment on children with cytomegalovirus infection

Objective To explore the risk factors of hearing impairment after cytomegalovirus (CMV) infected in children. Methods A total of 275 hospitalized cases of children with CMV infected were collected from the Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University during 2013 and 2015. The clinical data and auditory brainstem response (ABR) results were retrospectively analyzed. Chi-square test and Logistic regression analysis were performed to identify the risk factors of hearing impairment after CMV infected. Results In 275 cases (totally 550 ears) , there were 73 cases with hearing impairment (34 cases lost hearing in both ears) and totally 107 ears, among which 79 ears were mild abnormality, 16 ears were medium abnormality, 8 ears were serious abnormality and 4 ears were extremely serious abnormality. Multifactors Logistic regression analysis showed that male (OR=2.042, 95%CI: 1.097-3.802) and cranial MRI abnormal (OR=2.999, 95%CI: 1.251-7.186) were independent risk factors for hearing impairment on children with CMV infected. The negative correlation were observed between hepatitis (OR=0.113, 95% CI: 0.020-0.637) , thrombocytopenia (OR=0.217, 95% CI: 0.056-0.842) and hearing impairment. Conclusions CMV infected male children and cranial MRI abnormal children combine with hearing impairment more common. The emergence of hepatitis and thrombocytopenic ecchymosis may contribute to the early detection and treatment of the disease so as to reduce the hearing impairment, but the exact mechanism needs further research. Key words: Cytomegalovirus; Hearing impairment; Risk factors