Retinal vessel oxygen saturation in patients suffering from inherited diseases of the retina.
2014
Purpose: The aim of this study was to evaluate the oxygen saturation in patients with
inherited diseases of the retina. Methods: Fundus oximetry images were taken using a
retinal vessel analyser (IMEDOS Systems UG, Jena, Germany). Retinal vessel oximetry was
performed in 53 eyes of 27 patients suffering from inherited retinal diseases and compared to 22
eyes of 11 healthy controls. The oxygen saturation in all four major retinal arterioles
(A-SO 2 ) and venules (V-SO 2 ) were measured and their difference (A − V
SO 2 ) was calculated. The data were compared within groups and to controls.
Results: Based on V-SO 2 values, the rod-cone dystrophy group (66.46 %; SD,
± 5.09) could well be differentiated from controls 54.02 % (SD, ± 3.04), from cone-rod
dystrophies 57.56 % (SD, ± 5.66), as well as from inherited maculopathies 58.42% (SD, ± 4.74).
The mean A-SO 2 in the rod-cone dystrophy group was increased to 98.96 % (SD, ± 6.06,
p < 0.014), while in the cone-rod group and in the maculopathy group it was 92.75 % (SD,
± 3.75), respectively 94.44 % (SD ± 4.85), closer to the normal values (92.68 %; SD, ± 3.53,
p > 0.05). The A − V SO 2 difference, as an indirect indicator for retinal oxygen
use, was reduced in the rod-cone patients, however only when the controls were taken into
account (p = 0.01). Conclusion: This is to our knowledge the first study which proposes
the retinal vessel oximetry to be a sensitive measure for differentiating rod-cone dystrophy
patients not only from controls, but also from patients with other inherited retinal
dystrophies.
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