A synthetic intrabody-based selective and generic inhibitor of GPCR endocytosis

Eshan Ghosh,Ashish Srivastava,Mithu Baidya,Punita Kumari,Hemlata Dwivedi,Kumari Nidhi,Ravi Ranjan,Shalini Dogra,Akiko Koide,Prem N. Yadav,Sachdev S. Sidhu,Shohei Koide,Arun K. Shukla

A synthetic intrabody-based selective and generic inhibitor of GPCR endocytosis

2017

Eshan Ghosh
Ashish Srivastava
Mithu Baidya
Punita Kumari
Hemlata Dwivedi
Kumari Nidhi
Ravi Ranjan
Shalini Dogra
Akiko Koide
Prem N. Yadav
Sachdev S. Sidhu
Shohei Koide
Arun K. Shukla

A synthetic antibody fragment can disrupt the interaction of a GPCR regulatory protein β-arrestin with clathrin, and thereby inhibit induced internalization of GPCRs.

Keywords:

Cell biology
Synthetic antibody
Internalization
Endocytosis
Nanotechnology
Regulation of gene expression
Clathrin
Physics
Intrabody
G protein-coupled receptor
Phage display
Allosteric regulation

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