KETAMINE THERAPY IN A PATIENT WITH TREATMENT-RESISTANT BIPOLAR DEPRESSION: A CASE REPORT

Summary: We present a clinical case of a patient with treatment-resistant bipolar depres- sion in which we conducted a course of ketamine infusions without the concomi- tant antidepressant treatment to be discontinued. Unlike most of the cited cases, this kind of treatment led to sustained improvement. There were no identified risks of induction of mania and cycling, as well as signs of drug dependence. It was assumed that whereas the initial impact of improvement was due to the ketamine infusions, the long-term effectiveness of the therapeutic response was linked with the concomitant antidepressant treatment.