EPOhr: FARMACOCINÉTICA, FARMACODINAMIA Y BIODISTRIBUCIÓN EN CONEJOS NUEVA ZELANDA / EPOhr: PHARMACOKINETICS, PHARMACODYNAMICS AND BIODISTRIBUTION IN NEW ZELAND RABBITS

La eritropoyetina humano recombinante es una glicoproteina natural y es obtenida por tecnicas humano recombinantes. Constituye la estructura base del biosimilar EPOCIM ® actualmente en la practica clinica nacional e internacional.  Es un medicamento de excelencia en el tratamiento de la anemia y se le atribuyen otras propiedades citoprotectoras en cerebro y corazon. Dado que en la literatura no se reporta una caracterizacion experimental del EPOCIM ® , el presente trabajo permite una caracterizacion integral desde el punto de vista farmacologico. Se determina en conejos Nueva Zelanda, los parametros farmacocineticos resultantes de aplicar el Analisis No Compartimental, la evaluacion Farmacodinamica de indices hematologicos y el patron de Biodistribucion por marcaje isotopico.  Los resultados coinciden con lo reportado para laepohr  por otros autores y correlacionan con los novedosos efectos terapeuticos investigados en la clinica. Palabras Clave: Eritropoyetina humano recombinante(epohr), farmacodinamia, efecto integral, marcaje isotopico, biodistribucion. Abstract Human recombinant erythropoietin is an endogenous glycoprotein wich is obtained industrially  by human recombinant techiniques. This molecule constitues the basis of hte biosimilar EPOCIM ® with wide introduction to the clinical practice, national and international. This biotechnologcial product is of excellence in the treatment of the anemia, with atribution of cytoprotection in brain and heart, now researching in the clinical practice. Due that doesn´t exists in the literature reports of experimental characterization, the aim of this paper is to offer an integral pharmacological evalutaion on EPOCIM ® . The experimental model was the New Zeland rabbit. It shows the pharmacokinetic parameters employing the Non Compartmental Analysis, the pharmacodynamic evaluation of heamtological indexes and the Biositribution empoyinf isotopical labeling of the molecule. There is a coincidence with the reportied for epohrbu different authors and it stablished a correlation with the novel therapeutic effects atribuitted in the clinical research now on its way. Keywords: Recombinate erythropoietin (epohr),pharmacodynamics, integral effect, isotopic labeling, bioidstribution.