Growth Hormone-Releasing Hormone Receptor Antagonist Modulates Lung Inflammation and Fibrosis due to Bleomycin

Chongxu Zhang,Renzhi Cai,Aaron Lazerson,Gaëtan J.-R. Delcroix,Medhi Wangpaichitr,Mehdi Mirsaeidi,Anthony J. Griswold,Andrew V. Schally,Robert M. Jackson

Growth Hormone-Releasing Hormone Receptor Antagonist Modulates Lung Inflammation and Fibrosis due to Bleomycin

2019

Chongxu Zhang
Renzhi Cai
Aaron Lazerson
Gaëtan J.-R. Delcroix
Medhi Wangpaichitr
Mehdi Mirsaeidi
Anthony J. Griswold
Andrew V. Schally
Robert M. Jackson

Purpose Growth hormone-releasing hormone (GHRH) is a 44-amino acid peptide that regulates growth hormone (GH) secretion. We hypothesized that a GHRH receptor (GHRH-R) antagonist, MIA-602, would inhibit bleomycin-induced lung inflammation and/or fibrosis in C57Bl/6J mice.

Keywords:

Anesthesia
Antagonist
Idiopathic pulmonary fibrosis
Growth hormone–releasing hormone
Endocrinology
Internal medicine
Hormone
Fibrosis
Receptor
Growth-hormone-releasing hormone receptor
Bleomycin
Medicine
Inflammation

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

Citations