Predictors of Kidney Tubular Dysfunction in HIV-Infected Patients Treated with Tenofovir: A Pharmacogenetic Study

P p .020 older age (odds ratio [OR], 1.1; 95% confidence interval [CI], 1.0‐1.2; ), lower body weight (OR, 0.9; P p .024 95% CI, 0.8‐0.9; ), and genotype CC at ABCC2 position 24 (OR, 5; 95% CI, 1.2‐21; ) were P p .048 P p .027 independently associated with KTD. Conclusions. Approximately 17% of HIV-infected patients treated with tenofovir had KTD. Homozygosity for the C allele at position 24 of the ABCC2 gene was strongly associated with KTD in this population. This polymorphism may help to identify patients at greater risk for developing tenofovir-associated tubulopathy, and close monitoring of renal function is warranted for these patients.