Immunotherapy – 2073. Therapeutic effect of mite allergen vaccines by subcutaneous route in allergic Cuban asthmatic patients

in the reduction of clinical symptoms (up to 32%, 95% CI:28-36%; p=0.0006) and medication intake (23%, 95% CI:18-28%), as compared to control treatment. The skin sensitivity to the allergens decreased significantly (p=0.0001), with regard to the beginning of the treatment. The allergen amount needed to induce a positive SPT increased 297-fold. Improvement of the lung function was observed, expressed in a modest Peak-Expiratory-Flow increase (p<0.05) and reduction of PEF daily variability. SIT was considered effective in 71% of patients. The frequency of local adverse reactions was 2.4 % of injections. Conclusions Summing up subcutaneous immunotherapy, using VALERGEN vaccines, is effective and safe for the control and amelioration of the asthma.