Diffusion imaging fibre tractographic analysis for auditory saccadic attention deficit (ASAD) in progression stages of Alzheimer's disease

Introduction The ability of human beings to perceive auditory stimulus in everyday acoustic environments depends on the localization and the identification of relevant sounds. Localization (or) the spatial orientation of the stimulus and relative motor output with saccadic eye and neck movements is analyzed by the tract from Auditory cortex (BA-41, 42) to Premotor Eye-Ear Field [PEEF] (BA-8b), called Auditory-saccadic pathway. Our study aimed on comparative analysis of this pathway in control adults with Alzheimer's Patients, using “Diffusion Imaging fibre Tractography”. We used 60 Diffusion Tensor Imaging (DTI) datasets (30 Males and 30 Females), between the age ranges from 55 to 100 yrs. Results Study reveals that, Bi-hemispheric deterioration of auditory saccadic pathway fibers were observed in females with AD, as compared to males. Whereas the auditory saccadic fibers are markedly increases in disease progression stages of males AD. Conclusion Present study proves the existence of neurostructural connectivity of Auditory-saccadic pathway (dorsal stream-auditory pathway) and the deterioration of this track leads to cause of Auditory saccadic attention deficit (ASAD) in Alzheimer's Patients. But, the results must to strongly evidence with functional and efficient connectivity analysis in future.