Endoscopic ultrasoud-guided fine-needle aspiration biopsy for extramural lesions of upper gastrointestinal tract

Objective To evaluate significance of EUS-FNA in diagnosis of extramural lesions of upper gastrointestinal tract. Methods EUS-FNA was performed in 33 patients with pancreatic lesions, 25 with mediastinal and 13 with retroperitoneal masses, and the clinical data of these patients were evaluated retrospectively. The final diagnosis was determined by surgical resection or clinical follow-up for 6 months. The sensitivity, specificity, positive predictive value （PPV） , negative predictive value （NPV） and accuracy of EUS-FNA for varies extramural lesions of upper gastrointestinal tract were analyzed. Results The overall diagnostic sensitivity, specificity, PPV, NPV, accuracy of EUS-FNA were 82. 2% （37/45）, 100. 0% （26/26）, 100. 0% （37/37）, 76. 5% （26/34）, 88. 7% （63/71）, respectively. There was no significant difference in sensitivity, specificity, PPV, NPV, accuracy of EUS-FNA in diagnosis for lesions less than 3cm and larger than 3cm. There was no procedure related complication occurred in all 71 patients. Conclusion EUS-FNA is a safe, accurate and successful procedure in the diagnosis for extramural lesions of the upper gastrointestinal tract regardless to its size. Key words: Biopsy, Fine-needle ;  Endoscopic ultrasonography ;  Diagnosis