Heterotopic Ossification negatively influences Range of Motion after Revision Total Knee Arthroplasty

Abstract Background The incidence of heterotopic ossification (HO) after total knee arthroplasty (TKA) varies and is of unclear clinical significance. This study aimed to identify the incidence of HO in patients undergoing revision TKA for either stiffness or aseptic loosening/instability and determine if the presence of HO is associated with inferior absolute range of motion (ROM) and ROM gains. Methods Eighty-seven patients were prospectively enrolled and separated into two cohorts to evaluate ROM after revision TKA (2017-2019). Group 1 (N=40) patients were revised for stiffness, while Group 2 (N=47) patients were revised for either aseptic loosening or instability. Goniometer-measured ROM values were obtained preoperatively and at 6-weeks, 6-months, and 1-year postoperatively. Statistical analysis included a Fisher’s exact test to assess for an association between preoperative HO and final ROM at 1 year after revision TKA. Results HO was identified on preoperative radiographs in 17 patients (20%). There was a significantly higher rate of preoperative HO in patients revised for stiffness compared to patients revised for instability or loosening (30% vs 11%; p=0.03). Five cases of HO qualitatively identified as most clinically severe were associated with lower ROM at each timepoint compared to the remainder of HO cases in this study cohort (p Conclusion The presence of HO is greater in patients undergoing revision TKA for stiffness. Additionally, HO severity appears to have a major effect on preoperative and postoperative ROM trajectory. This information should help guide patient expectations and highlights the need for a comprehensive, standardized classification system for HO.