The protective effect of Dexmedetomidine on perioperative myocardial injury in elderly hypertension patients

Objective To determine the effect of dexmedetomidine in elderly.hypertension patients undergoing hip replacement surgery.Methods Thirty patients with hypertension of Ⅱ degree aged ＞ 65yr undergoing hip replacement surgery were randomly divided into dexmedetomidine group(D) and control group(C) with 15 cases each.Anesthesia induction and maintenance were same in two groups.In group D,dexmedetomidine Was administered intravenously at 0.7 μg/(kg·h)after a bolus infusion at 1μg/(kg·h)for 10 min.Changes of HR、SBP、DBP were monitored before anesthesia,after induction,intubation and extubation,The changes in ST segment were recorded before anesthesia,after intubation and immediately after extubation.Results HR、SBP、DBP decreased significantly after induction compared with that of before anesthesia in two groups(P＜0.05,P＜0.01)while group D were lower than that of group C after intubation and immediately after extubation.The cases of ST segment showing myocardial injury were significantly differences between group D and group C(5 VS 1)(P＜0.05).Conclusion Dexmedetomidine intravenously could attenuate the degree of myocardial damage in elderly hypertension patients undergoing hip replacement surgery. Key words: Dexmedetomidine; Hypertension; Myocardial protection