97 Practicing knowledge translation: building awareness and assessing barriers and facilitators to provincial implementation of the proactive molecular risk classifier for endometrial cancer (ProMisE)

Objectives In preparation for provincial implementation of ProMisE molecular classification, two KT objectives were identified: 1) build awareness of ProMisE with first line knowledge users (KUs); and 2) elucidate barriers and facilitators to KUs use of ProMisE. Methods KUs were defined as pathologists, and clinicians (general practitioners, gynecologists, and oncologists) from rural and urban centres. The KT intervention was an explanatory video reviewing the rationale and relevance of molecular classification via three segments: ProMisE overview, clinician-focused, and pathologist-focused. Dissemination of the video to KUs occurred using a mixed-methods approach in two phases: I: KUs were exposed to the video and survey through institutional listservs; II: KUs were engaged for in-person viewing and focus group. Results The survey received 41 partial and 37 complete responses with representation from all targeted KUs: gynecologists(62.2%), oncologists(rad+gyn-oncs+other 32.4%), pathologists(5.4%) and all provincial health authorities. 95.1% of KUs watched the ProMisE overview, with 80.5% and 68.3% completing the clinician and pathology segments, respectively. Over 90% of respondents reported it having contained enough information to understand the advantages, and 64% felt ProMisE would be useful to guide management. KUs across specialties participated in a focus group (n=19;7 rural) to identify barriers and facilitators to implementation. Thematic analysis of survey and focus group illuminated implementation concerns related to cost, availability, accessibility, process, training, and interpretation of the test. Conclusions Motivation and engagement for EC molecular classification was recognized by KUs with implementation concerns. Addressing cross-provincial access, process, and timely results will ensure rapid uptake and fidelity.