Facile Synthesis of Surface Functionalized Pd 2+ @P-CDP/COFs for Highly Sensitive Detection of Norfloxacin Based on the Host-Guest Interaction

In this work, β-cyclodextrin porous polymers (P-CDPs) functionalized novel covalent organic frameworks (P-CDPs/COFs) were synthesized by a simple and facile method. After combined with Pd2+ via electrostatic interaction, the Pd2+@P-CDP/COFs nanocomposites were prepared and as novel electrode materials to fabricate NF sensor. Due to the host-guest recognition, excellent adsorption performance and catalytic performance of Pd2+ @Pd2+@P-CDP/COFs, the prepared sensor exhibited excellent electrochemical performance for detecting NF under the optimum conditions with the linear range of 0.08 to 7.0 μM and 7.0 to 100.0 μM, and the low detection limit 0.031 μM(S/N=3). Additionally, with the advantages of good selectivity and reproducibility, the obtained sensor could be successfully applied to measure NF with satisfactory results in the real medicinal samples of Norfloxacin eye-drops. Our findings paved the way for the design of modified COFs materials as a sensing platform and expanded the application of COFs modified materials in drug testing.