Abstract 17337: Ivabradine and Carvedilol on Rest and Stress Coronary Diastolic Perfusion Time in Patients With Stable Coronary Artery Disease

Background: We have already demonstrated that ivabradine has a better effect on coronary flow velocity reserve (CFVR) compared with bisoprolol, in patients with stable coronary artery disease (CAD), despite a similar heart rate reduction. The aim of our study was to compare, for the first time in humans, differences between ivabradine and carvedilol on coronary diastolic perfusion time, assessed by Doppler echocardiography, both at rest and after stress test, in patients with stable CAD. Methods: 82 patients with stable CAD were enrolled. Stress echocardiography was performed using dypiridamole (0.84 mg/kg). Coronary diastolic perfusion time (CDPT) and diastolic perfusion time to RR interval ratio (CDPT/RR) were calculated at baseline and after stress test. Patients were randomly assigned to carvedilol and ivabradine for one month and then stress echocardiography was performed again. Results: There were no significant differences in baseline characteristics between ivabradine and carvedilol group. CFVR wa...