Comparison of efficacy of multiple treatment regimen for T cell non-Hodgkin lymphoma

Objective To evaluate the efficacy of multiple chemotherapy regimens for T cell nonHodgkin lymphoma.Methods 40 cases of T cell non-Hodgkin lymphoma were treated with three different regimens.15 cases were treated with CHOP regimen;18 cases with CTOP regimen;7 cases with CTOPL regimen;and 6 cases in skin T cell non-Hodgkin lymphoma were treated with Interferon.Results In the CHOP group 10 cases(66.7 %)achieved complete remission(CR),2 cases(13.3 %)PR,and 3 cases(20.0 %)PD.In the CTOP group 13 cases(72.2 %)achieved CR,3 cases(16.7 %)PR,one case(5.6 %)PD,and one case(5.6 %)died at the early stage.In the CTOPL group 5 cases(71.4 %)achieved CR,and 2 cases (28.6 %)PR.Three group were compared with each other,respectively,and there was no statistical difference (P ＞0.05).In the Interferon group all patients achieved CR.In the CHOP group 2 patients of skin lymphoma achieved the long term survival,but in the CTOP and CTOPL groups of 7 patients survived long term.Conclusion CTOP and CTOPL regimen may be more effective for treatment of T cell non-Hodgkin lymphoma with better long term survival rate,but further investigation to overcome the drug resistance in T cell nonHodgkin iymphoma needs to be carried out. Key words: T-lymphocytes; Lymphoma,non-Hodgkin; Drug therapy,combination